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Nutramax Denamarin Liver Supplement for Dogs, with 225 mg of SAMe for all dog sizes supports liver function. When liver function is compromised, the exact cause can often be difficult to determine. Administering SAMe (S-Adenosylmethionine), which is found in Denamarin, has been shown to markedly increase liver levels of glutathione, an important compound for liver health formed when SAMe is metabolized. The SAMe in Denamarin has also been shown to help protect liver cells from cell death and may help cell repair and regeneration. Denamarin also helps support your dog's liver through the administration of silybin. Silybin is an active part of an extract from milk thistle, known as silymarin, and has been shown to support liver function by helping maintain a healthy oxidative balance. Denamarin Chewable Tablets allow dogs to receive SAMe and silybin in a tasty treat, eliminating the need to "pill" your dog daily. Additionally, the chewable tablets allow for quicker uptake of the SAMe and less variability between dogs when compared to enteric-coated tablets.